JULÄINE™ of Sweden | Evolving the Aesthetic Industry

The science behind collagen regeneration

JULÄINE™: Inspired by nature, proven by science.

JULÄINE™ is a new solution in the field of regenerative aesthetic injectables. Our approach is to reveal the beauty that already exists within each of us by supporting the body’s natural ability to regenerate and rejuvenate. With a strong belief in the power of natural regeneration and dedicated scientific research, JULÄINE™ was created to reactivating the natural collagen production, smoothening wrinkles and tightening the skin.

Developed with the unique LASYNPRO™ microsphere technology, JULÄINE™ harnesses the regenerative potential of Lactic Acid to deliver long-lasting, natural-looking results that feel authentic and real. The JULÄINE™ formula ensures the progressive and effective correction of lines and wrinkles (*) through collagen regeneration in a natural way.

(*) JULÄINE™ is an injectable implant for adult immune-competent individuals. It is intended for the correction of mild to severe nasolabial folds.

The role of poly-L-lactic acid

Central to the functioning of JULÄINE™ is poly-L-lactic acid (PLLA), a well-studied ingredient used in regenerative aesthetics. PLLA works by gradually stimulating fibroblast cells: The cells involved in producing natural collagen. As the PLLA microspheres biodegrade over time, they encourage the skin to regenerate new, healthy collagen in a natural and low-inflammatory way.

Clinical studies have shown that PLLA can activate fibroblast activity and support long-lasting facial rejuvenation through natural collagen regeneration.

Biocompatibility

PLLA is well tolerated by the body and gradually biodegrades over time. It has been shown to be non-toxic and gently integrates into the skin, supporting a balanced and natural collagen renewal response.

Controlled collagen activation

As PLLA particles dissolve, they stimulate fibroblasts to produce natural collagen, progressively smoothening wrinkles and tightening the skin.

Proven regenerative mechanism

Research confirms PLLA’s ability to enhance collagen synthesis and reduce the appearance of skin laxity and wrinkles over time, making it a trusted foundation in modern facial aesthetics.

A science-driven rejuvenation process with LASYNPRO™

Unlike trauma-based treatments that rely on micro-injury to stimulate repair, JULÄINE™ works through a low-inflammatory, biology-aligned process. Once injected, the PLLA microspheres integrate gradually into the skin, where they are gradually recognized by fibroblasts, the skin’s collagen-producing cells. This gentle activation reinforces the skin’s structure without unnecessary inflammation or irritation.

What makes this process unique is the LASYNPRO™ technology: a system that creates PLLA microspheres with highly uniform size and shape. Once injected, these microspheres are evenly dispersed into the skin, where they gradually engage fibroblast cells. As the PLLA microspheres biodegrade into lactic acid, a compound naturally found in the skin, this gentle biological response helps smoothen wrinkles and tighten the skin in a gradual and balanced way.

The skin rejuvenating treatment experts trust in

JULÄINE™ is designed to naturally activate the body’s own regeneration for long-lasting and natural-looking results that feel authentic, revealing beauty that was already yours.

01 | 04

Clinical insights and scientific validation

The science behind JULÄINE™ is supported by clinical research demonstrating its effectiveness, its high safety profile and its regenerative way of working.. Through rigorous testing and peer-reviewed research, JULÄINE™ continues to establish its position as a trusted innovation in medical aesthetics, offering both practitioners and patients a reliable, evidence-based approach to facial rejuvenation and beautification.

Proven collagen activation

PLLA has been shown to activate fibroblast cells: The cells involved in producing natural collagen. This activation leads to smoothening of wrinkles and tightening of the skin.

Low-inflammatory and well-tolerated

Biocompatibility testing demonstrates that PLLA microspheres trigger a low-inflammatory response by biodegrading in a controlled way. This results in a treatment that is designed to be gentle and well–tolerated.

Long-lasting regenerative effects

Clinical studies indicate that collagen stimulation can continue for several months, contributing to long-lasting improvements in skin smoothness and overall skin quality.

Clinically demonstrated aesthetic results

Clinical trials on nasolabial folds showed visible improvement in smooething of wrinkles and tightening of the skin, with results progressing gradually over 2-6 months.

Are you a healthcare professional?

Access detailed materials on PLLA-based collagen stimulation – exclusively available to certified medical professionals.

1 | 5

View clinical study

Contact us

Whether you're a health care professional looking to partner with us or a patient seeking information, we’re here to help you every step of the way.

I would like to receive news and marketing communicationfrom Nordberg Medical via e-mail.

I accept the Terms of Condition of Nordberg Medical. Information about the processing of pesonal data can be found in our privacy policy